Recent Advances in Engineered Materials for Immunotherapy-Involved Combination Cancer Therapy

Immunotherapy that can activate immunity or enhance the immunogenicity of tumors has emerged as one of the most effective methods for cancer therapy. Nevertheless, single-mode immunotherapy is still confronted with several critical challenges, such as the low immune response, the low tumor infiltration, and the complex immunosuppression tumor microenvironment. Recently, the combination of immunotherapy with other therapeutic modalities has emerged as a powerful strategy to augment the therapeutic outcome in fighting against cancer. In this review, recent research advances of the combination of immunotherapy with chemotherapy, phototherapy, radiotherapy, sonodynamic therapy, metabolic therapy, and microwave thermotherapy are summarized. Critical challenges and future research direction of immunotherapy-based cancer therapeutic strategy are also discussed.

Automated summary

Immunotherapy combined with other therapeutic modalities is an effective strategy to enhance cancer treatment outcomes. Recent research has focused on the combination of immunotherapy with chemotherapy, phototherapy, radiotherapy, etc., while also discussing critical challenges and future research directions.