Chemically and Biologically Engineered Bacteria-Based Delivery Systems for Emerging Diagnosis and Advanced Therapy

Bacteria are one of the main groups of organisms, which dynamically and closely participate in human health and disease development. With the integration of chemical biotechnology, bacteria have been utilized as an emerging delivery system for various biomedical applications. Given the unique features of bacteria such as their intrinsic biocompatibility and motility, bacteria-based delivery systems have drawn wide interest in the diagnosis and treatment of various diseases, including cancer, infectious diseases, kidney failure, and hyperammonemia. Notably, at the interface of chemical biotechnology and bacteria, many research opportunities have been initiated, opening a promising frontier in biomedical application. Herein, the current synergy of chemical biotechnology and bacteria, the design principles for bacteria-based delivery systems, the microbial modulation, and the clinical translation are reviewed, with a special focus on the emerging advances in diagnosis and therapy.

Automated summary

Bacteria, with their intrinsic biocompatibility and motility, have been utilized as an emerging delivery system in various biomedical applications, drawing wide interest in the diagnosis and treatment of diseases. The synergy of chemical biotechnology and bacteria has opened up many research opportunities, creating a promising frontier in biomedical applications. Research on bacteria-based delivery systems is focusing on emerging advances in diagnosis and therapy, bringing new possibilities to the field.