期刊
ADVANCED MATERIALS
卷 34, 期 25, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202103882
关键词
chemical synthesis; chemoselectivity; dynamic catalytic cycle; organic catalysis; single-atom catalyst
类别
资金
- NRF-CRP grant Two-Dimensional Covalent Organic Framework: Synthesis and Applications by National Research Foundation, Prime Minister's Office, Singapore [NRF-CRP16-2015-02]
- National University of Singapore Academic Research Fund [R-143-000-B57-114]
The limited scope of single-atom catalysts in liquid-phase transformations is due to stability issues and the inability to activate complex substances. A better design of the catalyst support is needed, and the chemical orthogonality of SAC is useful for designing tandem or multicomponent reactions.
To date, the scope of single-atom catalysts (SAC) in liquid-phase transformations is rather limited owing to stability issues and the inability to activate complex substances. This calls for a better design of the catalyst support that can provide a dynamic coordination environment needed for catalytic action, and yet retain robustness against leaching or aggregation. In addition, the chemical orthogonality of SAC is useful for designing tandem or multicomponent reactions, in which side reactions common to metal nanoparticles are suppressed. In this review, the intrinsic mechanism will be highlighted that controls reaction efficiency and selectivity in SAC-catalyzed pathways, as well as the structural dynamism of SAC under complex liquid-phase conditions. These mechanistic insights are helpful for the development of next-generation SAC systems for the synthesis of high-value pharmaceuticals through late-stage functionalization, sequential and multicomponent strategies.
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