期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 50, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202107540
关键词
cancer; cancer immune cycle; immune response; immunotherapy; intelligent strategies
类别
资金
- National Natural Science Foundation of China [21927811, 21874086]
- Youth Innovation Science and Technology Program of Higher Education Institution of Shandong Province [2019KJC022]
This review discusses the key factors in each step of the cancer immune cycle and emphasizes the importance of intelligent therapeutic strategies for modulating immune surveillance against cancer. Suggestions for constructing new intelligent strategies are proposed to make antitumor immunity more effective and advance the development of cancer immunotherapy.
The immune system is composed of immune organs, immune cells, and immunoactive substances, which plays a vital role in antitumor immunity in cancer immunotherapy. During the process of the antitumor immune response, many factors are involved in the cancer immune cycle. Therefore, developing intelligent strategies based on the steps of the cancer immune cycle to elicit the immune responses for enhanced cancer immunotherapy is of great significance. In this review, the key factors in each step of the cancer immune cycle are discussed, and then, the intelligent therapeutic strategies for modulating the immune surveillance against cancer are highlighted. Considering the demand for cancer immunotherapy in clinic, some suggestions for constructing new intelligent strategies are also put forward, which will make antitumor immunity more effective and advance the development of cancer immunotherapy.
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