期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 49, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202106705
关键词
amyloid; chronic wounds; intrinsic versatile hydrogel; peptide assembly; wound dressings
类别
资金
- National Natural Science Foundation of China [81772364, 21908059, 41907318, 21636003]
- Medical Guidance Scientific Research Support Project of Shanghai Science and Technology Commission [19411962600]
- China Postdoctoral Science Foundation [2019M651419]
- Shanghai Sailing Program [19YF1410900]
- Fundamental Research Funds for the Central Universities [22221818014]
- Shanghai Post-doctoral Excellence Program [2018011]
- Open Funding Project of the State Key Laboratory of Bioreactor Engineering
This study investigated a versatile hydrogel based on amyloid-derived toxin simulant, which promotes angiogenesis, has broad-spectrum antibacterial activity, and accelerates wound healing for diabetic patients, showing great potential for clinical application.
Persistent microbial infection and decreased neovascularization are common issues associated with diabetic wound treatment. Hydrogel dressings that offer intrinsic antibacterial and angiogenesis-inducing may substantially avoid the use of antibiotics or angiogenic agents. Herein, a versatile hydrogel is fabricated using an amyloid-derived toxin simulant (Fmoc-LFKFFK-NH2, FLN) as building blocks, inspired by the defense strategy of Staphylococcus aureus (S. aureus). The simulant assemblies of the hydrogel function as both matrix components and functional elements for diabetic wound treatment. The hydrogel undergoes quick assembly from random monomers to nanofibrils with abundant b-sheet driven by multiple non-covalent interactions. The developed hydrogel demonstrates excellent biocompatibility and accelerates angiogenesis via hypoxia-inducible factor 1 alpha (HIF-1 alpha) and vascular endothelial growth factor A (VEGFA) signaling as a consequence of its amyloidal structure. The simulant-based nanofibrils endow the hydrogel with broad-spectrum antibacterial activity dominated by a membrane-disruption mechanism. In addition, the hydrogel exhibits excellent performance compared with the commercial hydrogel Prontosan in accelerating wound healing of diabetic mice infected with methicillin-resistant S. aureus (MRSA). This study highlights the fabrication of a single component and versatile hydrogel platform, thereby avoiding the drug-related side effects and complicated preparations and demonstrating its profound potential as a clinical dressing for the management of microbe-infected diabetic wounds.
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