期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 45, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202104441
关键词
alginate; biomaterial inks; bovine serum albumin; four-axis printing; tannic acid
类别
资金
- National Research Foundation of Korea (NRF) [2015R1A2A1A10054592, 2021H1D3A2A02044451]
By combining polysaccharide-tannic acid-protein bioconjugate, a novel hydrogel ink is successfully developed with 3D printability, shear-thinning, electroconductivity, multiple crosslinking mechanisms, and cytocompatibility without the use of chemical crosslinking agents. This offers promising results for addressing challenges in 3D printing.
A successful 3D printable hydrogel ink needs not only biofunctionalities but also minimal fabrication steps such as multiple crosslinking sites, high printability, cytocompatibility, high shape fidelity, stability, shear thinning, robust properties, and less time-consuming processing steps, by maximizing known material chemistries and functionalities. This work reports a novel bioinspired conjugate with polysaccharide (alginate)-tannic acid (TA)-protein (bovine serum albumin) to fabricate proteoglycan-like gels, which are 3D printable with multilayers, shear-thinning, elastic, electroconductive (with carbon nanotubes), controlled crosslinking/degradation through multiple crosslinking mechanisms (TA, Ca2+ ions, and NaIO4 oxidation), and interactions with cytocompatible hydrogel system. The synthesis process is simple, and gelation (within 2 h) is ensured without any chemical crosslinking agents (at room temperature). While cell-adhesive albumin largely improves cytocompatibility, carbon nanotubes in the gel give electrical conductivity in the different four-axis 3D printed structures, including large hollow tubular constructs. This work demonstrates promising results of electroconductive proteoglycan-like gel ink to address the challenges in 3D/four-axis ink printing such as synthesis, printability, shape fidelity, electroconductivity, controlled fabrication and degradation, cytocompatibility, and multiple crosslinking abilities to maintain the dimensions of the diversely printed constructs.
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