期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 37, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202103134
关键词
chemoreactive nanomedicine; Janus nanoparticles; mutual promotion; sonodynamic therapies; tumor therapies
类别
资金
- National Key R&D Program of China [2016YFA0203700]
- National Natural Science Foundation of China [81471669, 81470079, 81971629, 81771848, 51672303]
- Excellent Young Scientist Foundation of NSFC [51722211]
- National Science Foundation for Young Scientists of China [51902334]
- Program of Shanghai Subject Chief Scientist [18XD1404300]
- Shanghai Sailing Program [19YF1453700]
- Scientific Program Fund of Shanghai Jiao Tong University School of Medicine [TM201618]
In this study, a TiO2-Fe3O4@PEG Janus nanostructure was designed and engineered for bilaterally enhanced SDT and CDT. The rational design not only improved the treatment efficacy but also addressed the major concerns of SDT, providing a promising approach for non-invasive therapy.
As a non-invasive treatment modality with high tissue-penetration depth, ultrasound-triggered sonodynamic therapy (SDT) has been extensively explored and is regarded as the alternative choice to overcome the drawbacks of conventional photo-triggered therapies. Nevertheless, the low quantum yield of sonosensitizer, tumor hypoxia, and undesirable therapeutic efficiency are still the major concerns of SDT. It is highly challenging but necessary to explore the SDT-based synergistic, augmented, and noninvasive therapeutic modalities. Herein, a distinct TiO2-Fe3O4@PEG Janus nanostructure composed of the typical sonosensitizer TiO2 and nanoenzyme Fe3O4 is rationally designed and engineered for bilaterally enhanced SDT and chemodynamic therapy (CDT). The deposition of Fe3O4 component on the surface of TiO2 can not only endow the Janus nanosonosensitizers with Fenton-catalytic activity to generate hydroxyl radicals (center dot OH) from tumor-endogenous overexpressed H2O2 for CDT but also enhance the SDT performance of TiO2 via narrowing the band gap of TiO2 and reducing the recombination rate of the electrons (e(-)/h(+)) pair. In turn, the US activation can both accelerate mass transfer and chemical reaction rates of the Fenton reaction to enhance the CDT effect. The high efficacy of bilaterally enhanced SDT and CDT is systematically demonstrated both in vitro and in vivo.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据