期刊
ADVANCED FUNCTIONAL MATERIALS
卷 31, 期 33, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202102583
关键词
adhesive hydrogels; hemostasis; quaternized chitosan; self-gelling powders; wet adhesion
类别
资金
- Research Grants Council of Hong Kong [14202920, 14204618]
- Hong Kong Research Grants Council Theme-based Research Scheme [T13-402/17-N]
- National Natural Science Foundation of China [81772394, 81972116]
- Key Program of Natural Science Foundation of Guangdong Province [2018B0303110003]
- China Postdoctoral Science Foundation [2020M682907]
- Shenzhen Science and Technology Projects [SGLH20161209105517753, JCYJ20170817172023838, JCYJ20170306092215436, JCYJ20170413161649437]
- Guangdong International Cooperation Project [2021A0505030011]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515110622]
- Impact Postdoctoral Fellowship Scheme of the Chinese University of Hong Kong
The PEI/PAA/QCS powder is an ultrafast self-gelling and wet adhesive hemostatic material that can quickly absorb blood and form a pressure-resistant physical barrier to stop bleeding effectively. It has been demonstrated to work well on various irregularly shaped, high-pressure bleeding wounds and can also promote wound healing.
Achieving rapid and effective hemostasis on irregularly shaped, non-compressible visceral, and high-pressure arterial bleeding wounds remains a critical clinical challenge. Herein, an ultrafast self-gelling and wet adhesive polyethyleneimine/polyacrylic acid/quaternized chitosan (PEI/PAA/QCS) powder is reported as the hemostatic material and wound dressing. PEI/PAA/QCS powder deposited on bleeding wounds can rapidly absorb a large amount of blood to concentrate coagulation factors. Meanwhile, the powder can form an adhesive hydrogel in situ within 4 s upon hydration to form a pressure-resistant physical barrier. Furthermore, PEI/PAA/QCS hydrogels can aggregate blood cells and platelets to enhance hemostasis. Depositing PEI/PAA/QCS powder on various bleeding wounds, including at the liver and heart, high-pressure femoral artery and tail vein of rats, arrests the bleeding around 10 s with no rebleeding after ten minutes. Excellent hemostasis of PEI/PAA/QCS powder is further demonstrated against massive hemorrhage in porcine spleen and liver in vivo, which are non-compressible organs with abundant blood supply. In addition, the powder can be used as a wound dressing to promote the healing of the full-thickness skin wounds. The advantages of PEI/PAA/QCS powder including rapid and effective hemostasis, effective wound healing, easy usage, low cost, and adaptability to fit complex target sites make it a promising biomaterial for surgical applications.
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