期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 173, 期 -, 页码 281-305出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.03.015
关键词
Tumor-on-chip; Microphysiological systems; Immunotherapy; In vitro models; Adoptive cell therapy; Immune checkpoint inhibitor; Cytokine therapy; Oncolytic viruses; Cancer vaccine
资金
- German Federal Institute for Risk Assessment [60010201.P581]
- European Union [845147]
- Innovative Medicines Initiative 2 Joint Undertaking (JU) [853988]
- European Union
- EFPIA
- JDRF INTERNATIONAL
The progress in cancer immunotherapy is hindered by obstacles, notably the lack of representative nonclinical models that can predict clinical outcomes. The emergence of immunocompetent Cancer-on-Chip models presents novel opportunities to address this challenge.
The advances in cancer immunotherapy come with several obstacles, limiting its widespread use and benefits so far only to a small subset of patients. One of the underlying challenges remains to be the lack of representative nonclinical models that translate to human immunity and are able to predict clinical efficacy and safety outcomes. In recent years, immunocompetent Cancer-on-Chip models emerge as an alternative human-based platform that enables the integration and manipulation of complex tumor microenvironment. In this review, we discuss novel opportunities offered by Cancer-on-Chip models to advance (mechanistic) immuno-oncology research, ranging from design flexibility to multimodal analysis approaches. We then exemplify their (potential) applications for the research and development of adoptive cell therapy, immune checkpoint therapy, cytokine therapy, oncolytic virus, and cancer vaccines. (c) 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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