4.7 Review

Zebrafish as a preclinical model for Extracellular Vesicle-based therapeutic development

期刊

ADVANCED DRUG DELIVERY REVIEWS
卷 176, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.addr.2021.05.025

关键词

Extracellular Vesicles; Live imaging; In vivo imaging; Zebrafish embryo; Biomarkers; Drug nano-vehicles; Intrinsic modulators

资金

  1. Fondation Recherche Alzheimer
  2. INCA PLBIO [PLBIO19-059]

向作者/读者索取更多资源

Extracellular Vesicles (EVs) released during various pathophysiological processes can propagate through biological fluids, target cells, deliver content, and elicit functional responses, offering potential as biomarkers and drug nano-vehicles. Advances in imaging EVs in vivo, particularly in zebrafish embryos, provide insights into EVs dynamics, biodistribution, and functions to enhance their development for therapeutic applications.
Extracellular Vesicles (EVs) are released during various pathophysiological processes and reflect the state of their cell of origin. Once released, they can propagate through biological fluids, target cells, deliver their content and elicit functional responses. These specific features would allow their harnessing as biomarkers, drug nano-vehicles and therapeutic intrinsic modulators. However, the further development of their potential therapeutic application is hampered by the lack of knowledge about how EVs behave in vivo. Recent advances in the field of imaging EVs in vivo now allow live-tracking of endogenous and exogenous EV in various model organisms at high spatiotemporal resolution to define their distribution, half-life and fate. This review highlights current imaging tools available to image EVs in vivo and how live imaging especially in the zebrafish embryo can bring further insights into the characterization of EVs dynamics, biodistribution and functions to potentiate their development for therapeutic applications. (c) 2021 Elsevier B.V. All rights reserved.

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