期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 174, 期 -, 页码 406-424出版社
ELSEVIER
DOI: 10.1016/j.addr.2021.04.025
关键词
Additive manufacturing; 3D printed drug products and oral dosage; forms; Formulation engineering and printlets; SLS; SLM; DMLS; EBM; MJF; Digital pharmaceutical sciences; Personalized pharmaceuticals and; medicines; Drug delivery systems and prosthesis
Powder bed fusion (PBF) is a 3D printing method that selectively consolidates powders into 3D objects using a power source. PBF technologies offer benefits such as superior printing resolution and speed, as well as the ability to create complex products without the need for secondary supports, making them well suited for bespoke drug-laden formulations, devices, and implants.
Powder bed fusion (PBF) is a 3D printing method that selectively consolidates powders into 3D objects using a power source. PBF has various derivatives; selective laser sintering/melting, direct metal laser sintering, electron beam melting and multi-jet fusion. These technologies provide a multitude of benefits that make them well suited for the fabrication of bespoke drug-laden formulations, devices and implants. This includes their superior printing resolution and speed, and ability to produce objects without the need for secondary supports, enabling them to precisely create complex products. Herein, this review article outlines the unique applications of PBF 3D printing, including the main principles underpinning its technologies and highlighting their novel pharmaceutical and biomedical applications. The challenges and shortcomings are also considered, emphasising on their effects on the 3D printed products, whilst providing a forward-thinking view. (c) 2021 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
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