期刊
ACTA TROPICA
卷 219, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.actatropica.2021.105918
关键词
-
资金
- Federal Ministry of Education and Research (BMBF) [01KA1611, 558 01KA1612]
- Health Africa project [01KA1611, 558 01KA1612]
- Wellcome Trust, International Intermediate Fellowship [559 201900/Z/16/Z]
Podoconiosis is a non-filarial and non-communicable disease caused by factors like contact with volcanic red clay soil, high altitude, high seasonal rainfall, and occupation. Despite its global presence, knowledge about related genetics, pathophysiology, immunology, and the causing molecule(s) in the soil remains uncertain, making podoconiosis one of the most neglected diseases.
Podoconiosis is a non-filarial and non-communicable disease leading to lymphedema of the lower limbs. Worldwide, 4 million individuals live with podoconiosis, which is accompanied by disability and painful intermittent acute inflammatory episodes that attribute to significant disability adjusted life years (DALYs). Different risk factors like contact with volcanic red clay soil, high altitude (above 1000 m), high seasonal rainfall (above 1000 mm/year) and occupation (e.g., subsistence farmer) are associated with the risk of podoconiosis. Although podoconiosis was described to be endemic in 32 countries in Africa, parts of Latin America and South East Asia, knowledge about related genetics, pathophysiology, immunology and especially the causing molecule(s) in the soil remain uncertain. Thus, podoconiosis can be considered as one of the most neglected diseases. This review provides an overview about this non-filarial related geochemical disease and aim to present perspectives and future directions that might be important for better understanding of the disease, prospect for point-of-care diagnosis, achieving protection and developing novel treatment strategies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据