期刊
ACTA PAEDIATRICA
卷 110, 期 9, 页码 2635-2640出版社
WILEY
DOI: 10.1111/apa.15954
关键词
associated malformations; birth prevalence; gastroschisis; mortality; termination of pregnancy
类别
资金
- Her Royal Highness Crown Princess Lovisa Foundation
- Sallskapet Barnavard Foundation
- Mag-Tarm Foundation
The study in Sweden found a stable birth prevalence of gastroschisis at 1.52 per 10,000 live births over a 20-year period. The mortality rate was low at 4.4%, but termination of pregnancies was high at 21%, with gastrointestinal anomalies being the most common associated anomalies.
Aim An increased incidence has been reported for the congenital abdominal wall defect gastroschisis. The reason for this increasing trend is not known, nor the aetiology. The aim of this study was to examine the national birth prevalence in Sweden, the termination rate, associated anomalies and the mortality of gastroschisis within the cohort. Methods A nationwide, population-based descriptive study of children born with gastroschisis in Sweden between 1/1 1997 and 31/12 2016 was conducted. The cohort was collected from the Swedish Medical Birth Register and the Swedish National Patient Register. Several other national registers were then interlinked to identify outcome data. Results The study included 361 cases of gastroschisis, 54% female. The birth prevalence was 1.52 in 10,000 live births. The termination rate was 21%. The mortality within the cohort was 4.4% with a 1-year mortality of 3.9%. Most frequent associated anomalies were gastrointestinal (11.4%), musculoskeletal (9.8%) and cardiovascular anomalies (7.9%). Conclusion During the 20-year study period, a stable birth prevalence of 1.52 per 10 000 live births was seen in Sweden. The mortality was low, 4.4%, but the termination of pregnancies was high, 21%. Almost one-third had associated congenital anomalies where gastrointestinal anomalies were the most common.
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