4.6 Article

Targeting cancer stem cells in medulloblastoma by inhibiting AMBRA1 dual function in autophagy and STAT3 signalling

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Summary: AMBRA1 has been identified as a key regulator in cell cycle control, playing a crucial role in maintaining genomic integrity by regulating the abundance of D-type cyclins and facilitating the transition from G1 to S phase, thereby preventing replication stress. The findings suggest that CHK1 kinase could be a potential therapeutic target in AMBRA1-deficient tumors, highlighting the importance of the AMBRA1-cyclin D pathway in regulating cell cycle and genomic stability in embryonic development and tumorigenesis.

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