4.5 Article

Dexmedetomidine maintains blood-brain barrier integrity by inhibiting Drp1-related endothelial mitochondrial dysfunction in ischemic stroke

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Cell Biology

New Insights into Stroke Prevention and Treatment: Gut Microbiome

Linna Zhao et al.

Summary: Stroke is a lethal neurological disease that poses a grave economic burden on society, yet there remains an absence of precise effective treatment strategies. The gut microbiota plays a significant role in stroke prevention and treatment, with interventions through symbiotic microorganisms showing promise in improving stroke prognosis.

CELLULAR AND MOLECULAR NEUROBIOLOGY (2022)

Article Biochemistry & Molecular Biology

Occludin degradation makes brain microvascular endothelial cells more vulnerable to reperfusion injury in vitro

Yuan Zhang et al.

Summary: In the context of ischemic stroke and tPA thrombolytic therapy, the degradation of occludin plays a crucial role in rendering blood-brain barrier endothelial cells more susceptible to reperfusion-associated stress stimuli.

JOURNAL OF NEUROCHEMISTRY (2021)

Article Anesthesiology

Dexmedetomidine Provides Cardioprotection During Early or Late Reperfusion Mediated by Different Mitochondrial K+-Channels

Annika Raupach et al.

Summary: Cardioprotective interventions such as pharmacological postconditioning using dexmedetomidine can protect hearts from ischemia and reperfusion injury, with different mitochondrial K+-channels being involved in mediating the protective effects during early and late reperfusion phases.

ANESTHESIA AND ANALGESIA (2021)

Review Cell Biology

Mitochondrial Fusion: The Machineries In and Out

Song Gao et al.

Summary: Mitochondria are dynamic organelles that undergo fusion and fission, which can impact their function and lead to diseases. Fusion of outer and inner mitochondrial membranes is mediated by dynamin-like proteins, but the molecular mechanisms behind this process remain unclear despite recent structural studies.

TRENDS IN CELL BIOLOGY (2021)

Review Pharmacology & Pharmacy

Targeting the blood-brain barrier for the delivery of stroke therapies

Anisha D'Souza et al.

Summary: This study discusses the viable strategy of targeting endothelial cells for drug delivery to facilitate neuroprotective effects, using BDNF as an example. It emphasizes the advances in cell-derived EVs for CNS targeting and drug delivery, as well as the potential of engineered EVs as an effective strategy to deliver drugs to the ischemic brain.

ADVANCED DRUG DELIVERY REVIEWS (2021)

Review Anesthesiology

Stroke in Surgical Patients A Narrative Review

Phillip E. Vlisides et al.

Summary: This review aims to provide evidence-based synthesis on perioperative stroke, covering its etiology, common risk factors, risk reduction strategies, screening methods for postoperative cerebral ischemia, and the impact of multidisciplinary collaborations on patient outcomes. It also highlights the clinical and scientific knowledge gaps that need to be addressed.

ANESTHESIOLOGY (2021)

Review Clinical Neurology

The future of neuroprotection in stroke

Angel Chamorro et al.

Summary: This article discusses research on neuroprotection, including the evaluation of potential neuroprotectants in preclinical models and some attempts in clinical trials. Some new developments and compounds show promise for improving neuroprotection, but further research and testing are needed.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2021)

Article Biochemistry & Molecular Biology

Inhibition of Drp1 SUMOylation by ALR protects the liver from ischemia-reperfusion injury

Jing Huang et al.

Summary: This study demonstrated that ALR protects mitochondria by affecting Drp1 SUMOylation, which in turn rescues hepatocytes from IRI-induced apoptosis. The findings provide a potential target for clinical intervention to reduce the effects of IRI during hepatic surgery.

CELL DEATH AND DIFFERENTIATION (2021)

Review Pathology

Mitochondrial Dynamics and Its Involvement in Disease

David C. Chan

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020 (2020)

Article Chemistry, Multidisciplinary

Melatonin receptor agonist ramelteon attenuates mouse acute and chronic ischemic brain injury

Xiao-li Wu et al.

ACTA PHARMACOLOGICA SINICA (2020)

Article Cell Biology

Melatonin attenuates vascular calcification by inhibiting mitochondria fission via an AMPK/Drp1 signalling pathway

Chen Wei Ren et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Article Cell Biology

Dexmedetomidine Protects against Ischemia and Reperfusion-Induced Kidney Injury in Rats

Naren Bao et al.

MEDIATORS OF INFLAMMATION (2020)

Review Neurosciences

Mitochondria dysfunction in the pathogenesis of Alzheimer's disease: recent advances

Wenzhang Wang et al.

MOLECULAR NEURODEGENERATION (2020)

Review Pharmacology & Pharmacy

New perspectives on the role of Drp1 isoforms in regulating mitochondrial pathophysiology

Ayeshah A. Rosdah et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Article Pharmacology & Pharmacy

The Protective Effect and Mechanism of Dexmedetomidine on Diabetic Peripheral Neuropathy in Rats

Yan-zhuo Zhang et al.

FRONTIERS IN PHARMACOLOGY (2020)

Article Multidisciplinary Sciences

TRPV4 promotes acoustic wave-mediated BBB opening via Ca2+/PKC-δ pathway

Wei-Hao Liao et al.

JOURNAL OF ADVANCED RESEARCH (2020)

Review Endocrinology & Metabolism

Regulation of blood-brain barrier integrity by microglia in health and disease: A therapeutic opportunity

Patrick T. Ronaldson et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2020)

Article Neurosciences

Mild hypoxia triggers transient blood-brain barrier disruption: a fundamental protective role for microglia

Sebok K. Halder et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)

Review Neurosciences

Endothelial Mitochondrial Dysfunction in Cerebral Amyloid Angiopathy and Alzheimer's Disease

Rebecca Parodi-Rullan et al.

JOURNAL OF ALZHEIMERS DISEASE (2019)

Article Clinical Neurology

MRI Guiding of the Middle Cerebral Artery Occlusion in Rats Aimed to Improve Stroke Modeling

Ilya L. Gubskiy et al.

TRANSLATIONAL STROKE RESEARCH (2018)

Article Biochemistry & Molecular Biology

FOXO1 inhibition potentiates endothelial angiogenic functions in diabetes via suppression of ROCK1/Drp1-mediated mitochondrial fission

Yundi Shi et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2018)

Article Cardiac & Cardiovascular Systems

Perioperative Major Adverse Cardiovascular and Cerebrovascular Events Associated With Noncardiac Surgery

Nathaniel R. Smilowitz et al.

JAMA CARDIOLOGY (2017)

Article Biochemistry & Molecular Biology

Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons

B. Oettinghaus et al.

CELL DEATH AND DIFFERENTIATION (2016)