期刊
ACS NANO
卷 15, 期 6, 页码 9434-9444出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.1c01600
关键词
intercellular communication; luminescence; photoswitchable protein; synthetic biology; predator-prey community
类别
资金
- MaxSynBio consortium - Federal Ministry of Education and Research (BMBF) of Germany [FKZ 031A359L]
- Max Planck Society
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [433682494 - SFB 1459]
The study demonstrates that cell to cell signaling through light is possible in artificial cell communities derived from biomimetic vesicles. The design allows for rapid propagation of light signals independent of diffusion, providing a blueprint for light based intercellular communication that can be used for programming artificial and natural cell communities.
Cells commonly communicate with each other through diffusible molecules but nonchemical communication remains elusive. While bioluminescent organism , communicate through light to find prey or attract mates, it is still under debate if signaling through light is possible at the cellular level. Here, we demonstrate that cell to cell signaling through light is possible in artificial cell communities derived from biomimetic vesicles. In our design, artificial sender cells produce an intracellular light signal, which triggers the adhesion to receiver cells. Unlike soluble molecules, the light signal propagates fast, independent of diffusion and without the need for a transporter across membranes. To obtain a predator-prey relationship, the luminescence predator cells is loaded with a secondary diffusible poison, which is transferred to the prey cell upon adhesion and leads to its lysis. This design provides a blueprint for light based intercellular communication, which can be used for programing artificial and natural cell communities.
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