期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 37, 页码 44556-44567出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c12409
关键词
photothermal conversion efficiency; photothermal therapy; gold nanoparticles; standardization; nanoheaters
资金
- NanoTBTech-H2020-FETOPEN [801305]
- Global Research Laboratory (GRL) Program through the National Research Foundation of Korea (NRF) - Ministry of Science and ICT, KRICT [2016911815, KK2061-23, SKO1930-20]
- National Research Council of Science & Technology (NST), Republic of Korea [KK2061-23] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Localized photothermal therapy is a promising method for combating cancer and enhancing other treatment modalities, but there is currently no consensus on how to accurately compare the light-to-heat conversion efficiency of different nanomaterials.
Localized photothermal therapy (PTT) has been demonstrated to be a promising method of combating cancer, that additionally synergistically enhances other treatment modalities such as photodynamic therapy or chemotherapy. PTT exploits nanoparticles (called nanoheaters), that upon proper biofunctionalization may target cancerous tissues, and under light stimulation may convert the energy of photons to heat, leading to local overheating and treatment of cancerous cells. Despite extensive work, there is, however, no agreement on how to accurately and quantitatively compare light-to-heat conversion efficiency (eta(Q)) and rank the nanoheating performances of various groups of nanomaterials. This disagreement is highly problematic because the obtained eta(Q) values, measured with various methods, differ significantly for similar nanomaterials. In this work, we experimentally review existing optical setups, methods, and physical models used to evaluate eta(Q). In order to draw a binding conclusion, we cross-check and critically evaluate the same Au@SiO2 sample in various experimental conditions. This critical study let us additionally compare and understand the influence of the other experimental factors, such as stirring, data recording and analysis, and assumptions on the effective mass of the system, in order to determine eta(Q) in a most straightforward and reproducible way. Our goal is therefore to contribute to the understanding, standardization, and reliable evaluation of eta(Q) measurements, aiming to accurately rank various nanoheater platforms.
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