期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 36, 页码 42429-42441出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c10818
关键词
electrospun fibers; biphasic hybrid; spinal cord injury; pastable fibers; adhesive fibers
资金
- Bio & Medical Technology Development Program [NRF-2019M3A9H1032791, NRF2018M3A9H2019045, NRF-2017M3A9B4061968]
- B a s i c S c i e n c e R e s e a r c h P r o g r a m [N R F 2018R1A2A2A05020786]
- National Research Foundation of Korea (NRF) - Korea government [21173MFDS562]
- Ministry of Food and Drug Safety
This study introduces a novel multifunctional adjuvant device, named the PAINT matrix, which can safely deliver therapeutic materials to target lesions. By integrating multiple technologies and systems, the PAINT matrix is capable of being injected into various cavities, pasted on tissue surfaces, and adhered to moisture-rich surfaces.
A critical challenge in many pharmaceutical fields is developing versatile adjuvant devices that can reduce the off-target delivery of therapeutic materials to target lesions. Herein, a biphasic hybrid fibrous system that can manipulate the spatial and temporal delivery of various therapeutic agents to target lesions by integrating multiple distinct systems and technologies such as fluffy coaxial electrospun polycaprolactone (PCL)/polystyrene (PS) fibers, cyclohexane-mediated leaching to remove PS layers selectively, amine display on PCL fibers, conjugation of naturally occurring adhesive gallol molecules onto hyaluronic acid (HA-g), and electrostatically complexing the aminated PCL fibers with the gallol-conjugated HA. In the context of paintable systems on target lesions, the resulting system is called a PAINT matrix (abbreviated according to the initial letter of its features: pastable, adhesive, injectable, nanofibrous, and tunable). Its viscoelastic property, which was attributed by coalescing aminated PCL fibers with viscous HA-g, enabled it to be noninvasively injected and fit into any cavity in the body with various morphologies, manually pasted on tissue surfaces, and adhered onto moisture-rich surfaces to ensure the secure delivery of therapeutics toward the target lesions. The PAINT matrix efficiently supplied immunomodulatory human neural stem cells (hNSCs) at rat hemisectioned spinal cord injury (SCI) sites and promoted both locomotive and sensory recovery in SCI models, presumably by protecting hNSCs against host immunosurveillance. The PAINT matrix will be broadly utilized for efficiently delivering therapeutics to difficult-to-reach target lesions by direct infusion or conventional biomaterialmediated approaches due to their locations, wet surfaces, or complicated ambient environments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据