期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 24, 页码 27920-27933出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c06059
关键词
zoledronic acid; VEGF; membrane nanovesicle; osteosarcoma; anti-osteolytic
资金
- National Natural Science Foundation of China [82001165]
- Changsha Municipal Natural Science Foundation [kq2007056]
- Independent Innovation Projects of Postgraduates of Central South University [2020zzts896]
- Hunan Provincial Natural Science Foundation of China [2020JJ8050]
A multifunctional nanodrug system (V-RZCD) targeting osteosarcoma has been developed in this study, which can inhibit the proliferation of osteosarcoma and significantly suppress osteolysis.
Chemotherapy is one of the main treatment methods for osteosarcoma. However, conventional chemotherapy lacks targeting properties, and its long-term and extensive use will have serious side effects on patients. For this reason, a multifunctional nanodrug system (V-RZCD) targeting osteosarcoma was developed in this study. V-RZCD consists of two parts: (1) the core (ZCD), wherein calcium ions (Ca2+) and zoledronic acid (ZA) form a metal-organic framework for loading doxorubicin (DOX), and (2) the shell (V-R), a vascular endothelial growth factor (VEGF) ligand-modified red blood cell membrane nanovesicle. By targeting the VEGF, V-RZCD can specifically bind to the VEGF receptors that are highly expressed on the surface of osteosarcoma cells. Importantly, compared with free ZA and DOX, V-RZCD not only clearly inhibits the proliferation of osteosarcoma but also significantly inhibits osteolysis induced by osteosarcoma. In summary, V-RZCD represents a new way to treat osteosarcoma.
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