期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 23, 页码 26748-26758出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c04949
关键词
ion transport; rectification; polyelectrolyte; iontronics; charge delivery
资金
- Samsung Research Funding Center of Samsung Electronics [SRFC-MA1402-53]
By utilizing a polyelectrolyte gel-filled micropipette, inverted ion current rectification can be used as a delivery probe to efficiently stimulate primary cultured neurons. This method allows for fine-tuning of current at a microscale, enhancing transport efficiency while minimizing leakages.
Ion current rectification (ICR), diodelike behavior in surface-charged nanopores, shows promise in the design of delivery probes for manipulation of neural networks as it can solve diffusive leakages that might be critical in clinical and research applications. However, it has not been achieved because ICR has restrictions in nanosized dimension and low electrolyte concentration, and rectification direction is inappropriate for delivery. Herein, we present a polyelectrolyte gel-filled (PGF) micropipette harnessing inverted ICR as a delivery probe, which quantitatively transports glutamate to stimulate primary cultured neurons with high efficiency while minimizing leakages. Since the gel works as an ensemble of numerous surface-charged nanopores, the current is rectified in the micro-opening and physiological environment. By extending the charge-selective region using the gel, inverted ICR is generated, which drives outward deliveries of major charge carriers. This study will help in exploring new aspects of ICR and broaden its applications for advanced chemical delivery.
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