期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 44, 页码 52174-52180出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c10891
关键词
zeolite; hydrophobic surface; hemostasis; adhesion; water absorbency
资金
- National Natural Science Foundation of China [91545113, 91845203, 21673206, 91853101]
- Shell Global Solutions International B. V. [PT71423, PT74557]
- Fok Ying Tong Education Foundation [131015]
- Science & Technology Program of Ningbo [2017C50014]
By modifying the surface of hydrophilic zeolite gauze with a paraffin coating, a hydrophobic dressing, PZ-Gauze, was prepared to reduce adhesion and blood loss without compromising coagulation activity. Unlike traditional gauze procoagulant theories, the hydrophobic modification did not affect the procoagulant performance, demonstrating a new approach to improving wound dressings.
To solve the problem of strong adhesion and excessive blood loss caused by the use of hydrophilic zeolite gauze (Z-Gauze) in uncontrollable bleeding, we have modified the surface of commercial Z-Gauze with a paraffin coating and prepared a hydrophobic dressing PZ-Gauze. After paraffin coating, the adhesion of Z-Gauze was reduced without an obvious decrease in coagulation activity. The clotting time of the hydrophobic PZ-Gauze was reduced from 378.3 to 154.6 s compared with that of cotton gauze, and the peeling force was decreased from 348.8 to 84.7 mN compared with that of Z-Gauze. Besides, PZ-Gauze can efficiently cut down the blood loss during treatment. On the basis of in vitro and in vivo experiments, it is confirmed that surface hydrophobic modification does not change the procoagulant performance because of the maintained cation exchange capacity of zeolites, and the reduced blood loss as well as enhanced difficulty for fibrin adhesion is attributed to its hydrophobicity. This is different from the traditional gauze procoagulant theories, where gauze hydrophilicity and procoagulant performance are always positively correlated.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据