期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 34, 页码 40302-40314出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c10821
关键词
mesoporous material; hollow sphere; ceria; catalysis; antibacterial therapy
资金
- National Natural Science Foundation of China [21701130]
- Key Research and Development Program of Shaanxi [2021GY-225]
- Foundation of State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering [2020-KF-42]
A nanoreactor with mesoporous structure and high specific surface area can efficiently convert glucose into highly toxic hydroxyl radicals, effectively killing bacteria and preventing biofilm formation without damage to normal tissues. This rational design of a nanoreactor shows potential applications in antibacterial therapy by enhancing catalytic activity.
Nanozyme has been regarded as one of the antibacterial agents to kill bacteria via a Fenton-like reaction in the presence of H2O2. However, it still suffers drawbacks such as insufficient catalytic activity in near-neutral conditions and the requirement of high H2O2 levels, which would minimize the side effects to healthy tissues. Herein, a mesoporous ceria hollow sphere/enzyme nanoreactor is constructed by loading glucose oxidase in the mesoporous ceria hollow sphere nanozyme. Due to the mesoporous framework, large internal voids, and high specific surface area, the obtained nanoreactor can effectively convert the nontoxic glucose into highly toxic hydroxyl radicals via a cascade catalytic reaction. Moreover, the generated glucose acid can decrease the localized pH value, further boosting the peroxidase-like catalytic performance of mesoporous ceria. The generated hydroxyl radicals could damage severely the cell structure of the bacteria and prevent biofilm formation. Moreover, the in vivo experiments demonstrate that the nanoreactor can efficiently eliminate 99.9% of bacteria in the wound tissues and prevent persistent inflammation without damage to normal tissues in mice. This work provides a rational design of a nanoreactor with enhanced catalytic activity, which can covert glucose to hydroxyl radicals and exhibits potential applications in antibacterial therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据