期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 31, 页码 36958-36966出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c11798
关键词
photothermal therapy; small-molecule nanomedicine; supramolecular assembly; passive targeting; active targeting
资金
- National Natural Science Foundation of China [51773107, 22071128, 51690152]
- Taishan Scholars Project of Shandong Province [tsqn201812072]
- Major Scientific and Technological Innovation Projects of key R&D programs in Shandong Province [2019JZZY021007]
- Shandong Provincial Natural Science Foundation [ZR2020ZD31]
Photothermal therapy allows precise treatment at the disease site. The development of Cy7-TCF-IMC nanosaucers presents a promising approach for imaging-guided precision therapy, showing effective antitumor therapy results.
Photothermal therapy allows spatiotemporal control of the treatment effect only at the site of the disease and provides promising opportunities for imaging-guided precision therapy. However, the development of photothermal transduction agents (PTAs) for tumor-specific accumulation and precision imaging, avoiding toxicity to the surrounding healthy tissue, is still challenging. Herein, a cyclooxygenase-2-specific small-organicmolecule-based PTA (Cy7-TCF-IMC) is developed, which can self-assemble into nanosaucers having unique photothermal and photoacoustic properties. Specifically, the self-assembling nature of Cy7-TCF-IMC affords preferential accumulation in tumors arising from synergistic passive enhanced permeability and retention effects and active targeting for precision theranostics. Antitumor therapy results show that these Cy7-TCF-IMC nanosaucers are highly photoacoustic imaging-guided PTAs for tumor ablation. These findings suggest the self-assembled Cy7-TCF-IMC nanosaucer represents a new paradigm as a single-component supramolecular medicine that can synergistically optimize passive and active targeting, thereby improving the therapeutic index of cancer and future clinical outcomes.
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