期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 24, 页码 27955-27962出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c06659
关键词
antibacterial biomimetic hydrogel; conjugated oligoelectrolyte; photodynamic therapy; polyisocyanide; reactive oxygen species
资金
- National Natural Science Foundation of China [21773054, 21905072, 51803046, 22077025]
- Natural Science Foundation of Hebei Province [B2020202062, B2020202086]
- Program for Top 100 Innovative Talents in Colleges and Universities of Hebei Province [SLRC2017028]
The study introduces a dual-component hydrogel composed of biomimetic polyisocyanopetide (PIC) hydrogel and a photodynamic antibacterial membrane-intercalating conjugated oligoelectrolyte (COE). The aggregation behavior and size of COEs in water can be controlled by the PIC hydrogel, leading to enhanced antibacterial efficiency. This strategy offers a straightforward method for developing biomimetic hydrogels with high antibacterial capability.
Fabricating antibacterial hydrogels with antimicrobial drugs and synthetic biocompatible biomimetic hydrogels is a promising strategy for practical medical applications. Here, we report a bicomponent hydrogel composed of a biomimetic polyisocyanopetide (PIC) hydrogel and a photodynamic antibacterial membrane-intercalating conjugated oligoelectrolyte (COE). The aggregation behavior and aggregate size of the COEs in water can be regulated using the PIC hydrogel, which could induce COEs with higher reactive oxygen species (ROS) production efficiency and increased association of COEs toward bacteria, therefore enhancing the antibacterial efficiency. This strategy provides a facile method for developing biomimetic hydrogels with high antibacterial capability.
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