期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 24, 页码 27963-27971出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c06740
关键词
photothermal therapy; nanomedicine; transition-metal dichalcogenides; PdTe2; near infrared
资金
- National Natural Science Foundation of China [51872188]
- Guang dong Special Support Program [JCYJ20170302151858466]
- Pengcheng Scholar Program [JCYJ20170818093808351]
- Shenzhen Peacock Plan [KQTD2016053112042971]
- Special Funds for the Development of Strategic Emerging Industries in Shenzhen [20180309154519685]
- SZU Top Ranking Project [86000000210]
- Hubei Key Laboratory of Plasma Chemistry and Advanced Materials [2020KF02]
The study successfully synthesized PdTe2 nanoparticles with excellent photothermal properties, encapsulated in DSPE-PEG to achieve high photothermal conversion efficiency and tumor inhibition effects. Under NIR-II laser irradiation, efficient tumor treatment of NIR-II photothermal nanoagents was achieved.
1T-phase transition-metal dichalcogenides (TMDs) nanomaterials are one type of emerging and promising near-infrared II (NIR-II) photothermal agents (PTAs) derived from their distinct metallic electronic structure, but it is still challenging to synthesize these nanomaterials. Herein, PdTe2 nanoparticles (PTNs) with a 1T crystal symmetry and around 50 nm in size are prepared by an electrochemical exfoliation method, and the corresponding photothermal performances irradiated under a NIR-II laser have been explored. The encapsulation of 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-poly(ethylene glycol) (DSPEPEG) endows PTNs with water solubility, enhanced photothermal stability, and high biocompatibility. Notably, PTN/DSPE-PEG displays a potent absorbance through the NIR-II zone and considerable photothermal conversion efficiency, which is up to 68% when irradiated with a 1060 nm laser. With these unique photothermal properties, excellent in vitro and in vivo tumor inhibition effects of PTN/DSPE-PEG have been achieved under the irradiation of a NIR-II (1060 nm) laser without visible toxicity to normal tissues, suggesting that it is an efficient NIR-II photothermal nanoagent.
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