4.8 Review

Chemical Modulators of Mucosal Associated Invariant T Cells

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The effects of 5-OP-RU stereochemistry on its stability and MAIT-MR1 axis

Takuro Matsuoka et al.

Summary: The study showed that the stereocenters at the 2'- and 3'- OH groups in the ribityl tail are crucial for MAIT cell activation, while the 4'- OH group does not significantly affect the regulation of MAIT cell activity. Furthermore, it was found that 5-OP-RU forms a covalent bond to MR1 in cells within 1 hour.

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Shunsuke Sakai et al.

Summary: The study found that MAIT cells mount minimal responses following Mtb infection, but MAIT cell expansion during chronic infection can reduce bacterial loads. The 5-OP-RU vaccination failed to protect against Mtb challenge, but MAIT cells play a role in delaying T cell priming.

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Synthesis, biological evaluation and molecular modelling of new potent clickable analogues of 5-OP-RU for their use as chemical probes for the study of MAIT cell biology

Thomas Yvorra et al.

Summary: MAIT cells are specialized alpha beta T lymphocytes that recognize microbial antigens derived from the riboflavin biosynthesis pathway. New ethinyl functionalized probes for studying MAIT cell biology have been developed and shown to efficiently activate specific MAIT cells. These probes can provide valuable insights into the dynamics of MAIT cell activation and antigen presentation at the cellular or organism level.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2021)

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Mucosal-Associated Invariant T Cell Effector Function Is an Intrinsic Cell Property That Can Be Augmented by the Metabolic Cofactor α-Ketoglutarate

Lauren J. Howson et al.

Summary: MAIT cells are an innate-like population of unconventional T cells that respond rapidly to microbial metabolite antigens or cytokine stimulation. Despite being described as effector memory cells, there is heterogeneity in MAIT cell effector response, which is not directly attributable to TCR clonotype or coreceptor expression. The TCR-dependent effector response of MAIT cells is epigenetically regulated and dependent on the availability of metabolic cofactors.

JOURNAL OF IMMUNOLOGY (2021)

Article Immunology

Outcome of SARS-CoV-2 infection is linked to MAIT cell activation and cytotoxicity

Heloise Flament et al.

Summary: Severe cases of COVID-19 are characterized by immune system dysfunction, particularly a significant reduction and high activation of mucosal-associated invariant T (MAIT) cells. These cells play a crucial role in disease severity and mortality, correlating with the activation of inflammatory cytokines and cytotoxic phenotype.

NATURE IMMUNOLOGY (2021)

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Identification and Phenotype of MAIT Cells in Cattle and Their Response to Bacterial Infections

Matthew D. Edmans et al.

Summary: MAIT cells are a population of innate-like T cells greatly conserved across species, including cattle. They play important roles in immune responses to bacterial infections, particularly in mucosal tissues. Cattle MAIT cells show similarities with human and murine MAIT cells, indicating a potential role in zoonotic infections.

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Francisella tularensis induces Th1 like MAIT cells conferring protection against systemic and local infection

Zhe Zhao et al.

Summary: MAIT cells play a crucial role in bacterial infections, providing protection against both systemic and local infections and forming stable memory cell populations.

NATURE COMMUNICATIONS (2021)

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Current Understanding of the Roles of CD1a-Restricted T Cells in the Immune System

Hyun Jung Yoo et al.

Summary: CD1a is a family of cell-surface glycoproteins that present lipid antigens to T cells. CD1a-restricted T cells can interact with the CD1a:lipid complex in various ways, potentially contributing to inflammatory skin disorders and other diseases.

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MAIT Cells in Health and Disease

Nicholas M. Provine et al.

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MAIT Cells Promote Tumor Initiation, Grow and Metastases via Tumor MR1

Juming Yan et al.

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MR1-Restricted T Cells Are Unprecedented Cancer Fighters

Alessandro Vacchini et al.

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Human MAIT cell cytolytic effector proteins synergize to overcome carbapenem resistance in Escherichia coli

Caroline Boulouis et al.

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Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentation of metabolite antigens

Hamish E. G. McWilliam et al.

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MAIT cell activation and dynamics associated with COVID-19 disease severity

Tiphaine Parrot et al.

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MAIT cells as attractive vaccine targets

A. Michael Downey et al.

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Hui-Fern Koay et al.

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MAIT cells are imprinted by the microbiota in early life and promote tissue repair

Michael G. Constantinides et al.

SCIENCE (2019)

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The effect of MR1 ligand glyco-analogues on mucosal-associated invariant T (MAIT) cell activation

Chriselle D. Braganza et al.

ORGANIC & BIOMOLECULAR CHEMISTRY (2019)

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An overview on the identification of MAIT cell antigens

Lars Kjer-Nielsen et al.

IMMUNOLOGY AND CELL BIOLOGY (2018)

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Recipient mucosal-associated invariant T cells control GVHD within the colon

Antiopi Varelias et al.

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MAIT cells protect against pulmonary Legionella longbeachae infection

Huimeng Wang et al.

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MAIT cells contribute to protection against lethal influenza infection in vivo

Bonnie van Wilgenburg et al.

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Antigen-loaded MR1 tetramers define T cell receptor heterogeneity in mucosal-associated invariant T cells

Rangsima Reantragoon et al.

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MR1 presents microbial vitamin B metabolites to MAIT cells

Lars Kjer-Nielsen et al.

NATURE (2012)

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Aerobic Glycolysis: Meeting the Metabolic Requirements of Cell Proliferation

Sophia Y. Lunt et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 27 (2011)

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Schiff Bases in Biological Systems

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