4.6 Review

The Evolution of Single-Cell Analysis and Utility in Drug Development

期刊

AAPS JOURNAL
卷 23, 期 5, 页码 -

出版社

SPRINGER
DOI: 10.1208/s12248-021-00633-6

关键词

flow cytometry; drug development; single cell

向作者/读者索取更多资源

This review briefly outlines the history and significance of cellular analysis tools, emphasizing the interplay between technological advancements and a deeper understanding of cellular biology, as well as the importance of cellular biomarkers in drug development. Recent advances in single-cell analysis are also highlighted for providing more robust cellular measurements and accelerating the development of novel therapies.
This review provides a brief history of the advances of cellular analysis tools focusing on instrumentation, detection probes, and data analysis tools. The interplay of technological advancement and a deeper understanding of cellular biology are emphasized. The relevance of this topic to drug development is that the evaluation of cellular biomarkers has become a critical component of the development strategy for novel immune therapies, cell therapies, gene therapies, antiviral therapies, and vaccines. Moreover, recent technological advances in single-cell analysis are providing more robust cellular measurements and thus accelerating the advancement of novel therapies.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据