期刊
JOURNAL OF INTEGRATIVE MEDICINE-JIM
卷 19, 期 4, 页码 362-373出版社
ELSEVIER
DOI: 10.1016/j.joim.2021.03.004
关键词
Antioxidants; Caenorhabditis elegans; Herbal formula; Lifespan extension; Rejuvenation medicine
资金
- Government Budget Grant 2017 [TTM610078S]
- Thailand Research Fund Senior Research Scholar
- Thailand Research Fund [RTA5880005]
Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Furthermore, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood. Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were identified.
Objective: This study explored the rejuvenation mechanisms of Thai polyherbal medicines using different approaches, including in vitro methods, as well as a well-defined nematode model, Caenorhabditis elegans. Methods: THP-R-SR012 decoction was selected from 23 polyherbal medicines, based on metal-chelating and chain-breaking antioxidant capacities. The influences of this extract on the survival and some stress biomarkers of C. elegans under paraquat-induced oxidative stress were evaluated. Furthermore, lifespan analysis and levels of lipofuscin accumulation were examined in senescent nematodes. The phytochemical profile of THP-R-SR012 was analyzed. Results: Supplementation with THP-R-SR012 decoction significantly increased the mean lifespan and reduced the oxidative damage to C. elegans under oxidative stress conditions. Further, THP-R-SR012 supplementation slightly influenced the lifespan and the level of lipofuscin accumulation during adulthood. Antioxidant-related phytochemical constituents of THP-R-SR012 decoction were rutin, naringenin, 3,4dihydroxybenzoic acid, gallic acid, glycyrrhizic acid, demethoxycurcumin and 18a-glycyrrhetinic acid. Conclusion: The antioxidant potential of THP-R-SR012 was due to its scavenging properties, its enhancement of antioxidant-related enzyme activities, and the presence of the antioxidant-related compound. These results support the traditional use of THP-R-SR012 decoction as a tonic for nourishing and strengthening the whole body. (C) 2021 Shanghai Changhai Hospital. Published by ELSEVIER B.V. All rights reserved.
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