期刊
MEMBRANES
卷 11, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/membranes11050343
关键词
amino acids; amphiphiles; chemical permeation enhancer; transdermal delivery; skin
类别
资金
- PT national funds (FCT/MCTES, Fundacao para a Ciencia e Tecnologia) [UIDB/50006/2020, PTDC/BTM-MAT/30624/2017]
- PT national funds (Ministerio da Ciencia, Tecnologia e Ensino Superior) [UIDB/50006/2020, PTDC/BTM-MAT/30624/2017]
- Fundação para a Ciência e a Tecnologia [PTDC/BTM-MAT/30624/2017] Funding Source: FCT
Transdermal drug delivery has advantages over conventional routes, but faces challenges due to the skin's natural barrier properties. Amino acid derivatives as permeation enhancers show great potential with high biodegradability and low toxicity, facilitating the delivery of various drugs through the skin.
Transdermal drug delivery (TDD) presents many advantages compared to other conventional routes of drug administration, yet its full potential has not been achieved. The administration of drugs through the skin is hampered by the natural barrier properties of the skin, which results in poor permeation of most drugs. Several methods have been developed to overcome this limitation. One of the approaches to increase drug permeation and thus to enable TDD for a wider range of drugs consists in the use of chemical permeation enhancers (CPEs), compounds that interact with skin to ultimately increase drug flux. Amino acid derivatives show great potential as permeation enhancers, as they exhibit high biodegradability and low toxicity. Here we present an overview of amino acid derivatives investigated so far as CPEs for the delivery of hydrophilic and lipophilic drugs across the skin, focusing on the structural features which promote their enhancement capacity.
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