期刊
ENEURO
卷 8, 期 2, 页码 -出版社
SOC NEUROSCIENCE
DOI: 10.1523/ENEURO.0052-21.2021
关键词
action; alcohol; compulsive; dependence; devaluation; orbitofrontal cortex
资金
- National Institute on Alcohol Abuse and Alcoholism [R00AA021780, R01AA026077, F31AA027439]
- Brain and Behavior Foundation
- National Science Foundation GRFP [DGE-1650112]
- Whitehall Foundation
Alcohol dependence can lead to deficits in decision-making and action control, with long-lasting changes in the orbitofrontal cortex function. Alcohol dependence disrupts goal-directed action control by enhancing activity associated with actions but diminishing outcome-related information in the OFC. This suggests a lasting disruption in OFC function induced by chronic alcohol exposure.
Alcohol dependence can result in long-lasting deficits to decision-making and action control. Neurobiological investigations have identified orbitofrontal cortex (OFC) as important for outcome-related contributions to goal-directed actions during decision-making. Prior work has shown that alcohol dependence induces long-lasting changes to OFC function that persist into protracted withdrawal and disrupts goal-directed control over actions. However, it is unclear whether these changes in function alter representation of action and outcome-related neural activity in OFC. Here, we used the well-validated chronic intermittent ethanol (CIE) exposure and withdrawal procedure to model alcohol dependence in mice and performed in vivo extracellular recordings during an instrumental task in which lever-press actions made for a food outcome. We found alcohol dependence disrupted goal-directed action control and increased OFC activity associated with leverpressing but decreased OFC activity during outcome-related epochs. The ability to decode outcome-related information, but not action information, from OFC activity following CIE exposure was reduced. Hence, chronic alcohol exposure induced a long-lasting disruption to OFC function such that activity associated with actions was enhanced, but OFC activity contributions to outcome-related information was diminished. This has important implications for hypotheses regarding compulsive and habitual phenotypes observed in addiction.
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