4.6 Review

The Unfolded Protein Response: An Overview

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Review Medicine, Research & Experimental

The molecular mechanism and functional diversity of UPR signaling sensor IRE1

Samirul Bashir et al.

Summary: The endoplasmic reticulum is responsible for protein folding and maturation, but can be affected by various stress conditions triggering the Unfolded Protein Response. This response involves the activation of sensors like IRE1 which signal to restore cellular homeostasis, and IRE1 can switch its substrate specificity to cotransnationally transported mRNAs in a process known as Regulated IRE1 Dependent Decay (RIDD).

LIFE SCIENCES (2021)

Review Biochemistry & Molecular Biology

The Roles of the Ubiquitin-Proteasome System in the Endoplasmic Reticulum Stress Pathway

Junyan Qu et al.

Summary: The endoplasmic reticulum (ER) is crucial for protein synthesis and metabolism in eukaryotic cells. When unfolded proteins exceed the ER's folding capacity due to environmental influences or increased protein synthesis, cells activate the endoplasmic reticulum stress (ER stress) response. The components of the ubiquitin-proteasome system (UPS), E3 ubiquitin ligases and deubiquitinases (DUBs), are closely related to ER stress.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Review Biochemistry & Molecular Biology

Quality Control in the Endoplasmic Reticulum: Crosstalk between ERAD and UPR pathways

Jiwon Hwang et al.

TRENDS IN BIOCHEMICAL SCIENCES (2018)

Article Biochemistry & Molecular Biology

Bypass of Activation Loop Phosphorylation by Aspartate 836 in Activation of the Endoribonuclease Activity of Ire1

Michael C. Armstrong et al.

MOLECULAR AND CELLULAR BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Getting RIDD of RNA: IRE1 in cell fate regulation

M. Maurel et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Review Cell Biology

Structural Basis of the Unfolded Protein Response

Alexei Korennykh et al.

ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 28 (2012)

Editorial Material Biochemistry & Molecular Biology

Unfolded protein response

Stewart Siyan Cao et al.

CURRENT BIOLOGY (2012)

Review Biotechnology & Applied Microbiology

A Review of the Mammalian Unfolded Protein Response

Anirikh Chakrabarti et al.

BIOTECHNOLOGY AND BIOENGINEERING (2011)

Article Cell Biology

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

Julie Hollien et al.

JOURNAL OF CELL BIOLOGY (2009)

Article Biochemistry & Molecular Biology

RNase domains determine the functional difference between IRE1α and IRE1β

Yusuke Imagawa et al.

FEBS LETTERS (2008)

Article Biochemistry & Molecular Biology

Dcr2 targets Ire1 and downregulates the unfolded protein response in Saccharomyces cerevisiae

Jinbai Guo et al.

EMBO REPORTS (2006)

Article Multidisciplinary Sciences

Decay of endoplasmic reticulum-localized mRNAs during the unfolded protein response

Julie Hollien et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

On the mechanism of sensing unfolded protein in the endoplasmic reticulum

JJ Credle et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Cell Biology

Role of Herp in the endoplasmic reticulum stress response

O Hori et al.

GENES TO CELLS (2004)

Article Biochemistry & Molecular Biology

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response

HY Jiang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Multidisciplinary Sciences

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells

KM Vattem et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

The ire1 and ptc2 genes involved in the unfolded protein response pathway in the filamentous fungus Trichoderma reesei

M Valkonen et al.

MOLECULAR GENETICS AND GENOMICS (2004)

Article Biochemistry & Molecular Biology

Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

YJ Ma et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Review Biochemistry & Molecular Biology

IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast

M Schröder et al.

MOLECULAR MICROBIOLOGY (2003)

Article Biochemistry & Molecular Biology

Enhancement of endoplasmic reticulum (ER) degradation of misfolded null Hong Kong α1-antitrypsin by human ER mannosidase I

N Hosokawa et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Biochemistry & Molecular Biology

Structure and intermolecular interactions of the luminal dimerization domain of human IRE1α

CY Liu et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Cell Biology

A time-dependent phase shift in the mammalian unfolded protein response

H Yoshida et al.

DEVELOPMENTAL CELL (2003)

Review Cell Biology

The unfolded protein response in nutrient sensing and differentiation

RJ Kaufman et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2002)

Article Biochemistry & Molecular Biology

Translational control is required for the unfolded protein response and in vivo glucose homeostasis

D Scheuner et al.

MOLECULAR CELL (2001)

Article Biochemistry & Molecular Biology

ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs

J Ye et al.

MOLECULAR CELL (2000)

Article Biochemistry & Molecular Biology

Regulated translation initiation controls stress-induced gene expression in mammalian cells

HP Harding et al.

MOLECULAR CELL (2000)

Article Biochemistry & Molecular Biology

Regulated step in cholesterol feedback localized to budding of SCAP from ER membranes

A Nohturfft et al.