期刊
FRONTIERS IN CARDIOVASCULAR MEDICINE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcvm.2021.636947
关键词
postprandial lipemia; triglyceride; atherosclerosis; endothelial dysfunction; oxidative stress; inflammation
资金
- National Natural Science Foundation of China [81202805, 81973689, 81573821, 82074254]
- Beijing Natural Science Foundation [7172185, 7202176]
Postprandial lipemia is closely related to cardiovascular disease and research focuses on TG, TRL, VLDL, CM, and remnant cholesterol. Interventions such as diet, exercise, and medications can improve postprandial lipemia, with novel drugs like pemafibrate, PCSK9, and apoCIII inhibitors garnering attention. Studies on the gut microbiota and its potential impact on lipid metabolism and postprandial lipemia warrant further investigation.
Postprandial lipemia plays an important role in the formation, occurrence, and development of atherosclerosis, and it is closely related to coronary heart disease and other diseases involving endothelial dysfunction, oxidative stress, inflammation, and other mechanisms. Therefore, it has become a focus area for further research. The studies on postprandial lipemia mainly include TG, TRL, VLDL, CM, and remnant cholesterol. Diurnal triglyceride patterns and postprandial hyperlipidemia are very relevant and are now insufficiently covered. The possible mechanisms between postprandial lipemia and cardiovascular disease have been reviewed in this article by referring to relevant literature in recent years. The research progress on the effects of postprandial lipemia on endothelial function, oxidative stress, and inflammation is highlighted. The intervention of postprandial lipemia is discussed. Non-medicinal intervention such as diet and exercise improves postprandial lipemia. As medicinal intervention, statin, fibrate, ezetimibe, omega-3 fatty acids, and niacin have been found to improve postprandial lipid levels. Novel medications such as pemafibrate, PCSK9, and apoCIII inhibitors have been the focus of research in recent years. Gut microbiota is closely related to lipid metabolism, and some studies have indicated that intestinal microorganisms may affect lipid metabolism as environmental factors. Whether intervention of gut microbiota can reduce postprandial lipemia, and therefore against AS, may be worthy of further study.
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