4.6 Review

The Immunomodulatory and Anti-Inflammatory Effect of Curcumin on Immune Cell Populations, Cytokines, and In Vivo Models of Rheumatoid Arthritis

期刊

PHARMACEUTICALS
卷 14, 期 4, 页码 -

出版社

MDPI
DOI: 10.3390/ph14040309

关键词

rheumatoid arthritis; curcumin; immune cells; immunomodulation; autoimmune disease

资金

  1. Wroclaw Medical University [STM.A010.20.135]

向作者/读者索取更多资源

Rheumatoid arthritis is a chronic autoimmune disorder that affects joints, leading to irreversible tissue degeneration and inflammation. Curcumin, a natural compound with anti-inflammatory properties, shows potential in modulating inflammatory responses and could play a role in the treatment of rheumatoid arthritis.
Rheumatoid arthritis (RA) is a widespread chronic autoimmune disorder affecting the joints, causing irreversible cartilage, synovium, and bone degradation. During the course of the disease, many immune and joint cells are activated, causing inflammation. Immune cells including macrophages, lymphocytes, neutrophils, mast cells, natural killer cells, innate lymphoid cells, as well as synovial tissue cells, like fibroblast-like synoviocytes, chondrocytes, and osteoclasts secrete different proinflammatory factors, including many cytokines, angiogenesis-stimulating molecules and others. Recent studies reveal that curcumin, a natural dietary anti-inflammatory compound, can modulate the response of the cells engaging in RA course. This review comprises detailed data about the pathogenesis and inflammation process in rheumatoid arthritis and demonstrates scientific investigations about the molecular interactions between curcumin and immune cells responsible for rheumatoid arthritis development to discuss this herbal drug's immunoregulatory role in RA treatment.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.6
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据