期刊
PHARMACEUTICALS
卷 14, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/ph14030284
关键词
vitamin D; inflammatory bowel diseases; Crohn's disease; ulcerative colitis; supplementation; deficiency
资金
- Medical University of Lodz [503/1-156-04/503-11-001-19-00]
- Polish National Agency for Academic Exchange Bekker programme
This study found that in patients with IBD, levels of 25(OH)D3 increased while 1,25(OH)2D3 levels did not change, and supplementation of vitamin D3 did not affect their levels. There was no significant correlation between pain intensity and vitamin D levels.
Due to its immunomodulatory effect, vitamin D has been associated with clinical parameters and outcomes in inflammatory bowel diseases (IBDs) which are chronic conditions of the gastrointestinal tract. Upon synthesis or digestion, vitamin D is metabolized in the liver to form 25(OH)D3, the major circulating metabolite. Further renal hydroxylation generates 1,25(OH)2D3, the most potent metabolite. Our aim was to examine the association between vitamin D levels, and its supplementation and pain intensity in 39 IBD patients and 33 healthy individuals. 25(OH)D3 and 1,25(OH)2D3 serum levels were measured. Each subject filled out visual analog scale (VAS) and Laitinen's pain assessment scales. Laboratory results were obtained, and disease activity was assessed. Linear regression was employed to investigate the correlation between 25(OH)D3, 1,25(OH)2D3 and pain intensity, clinical activity parameters, C-reactive protein, disease duration, and dietary habits. In IBD patients, 25(OH)D3 was increased, whereas 1,25(OH)2D3 was not. Vitamin D3 supplementation did not influence their levels. No correlation was found between pain scores, disease activity, inflammatory status, disease duration or dietary habits and both forms of vitamin D. Elevated 25(OH)D3 and normal 1,25(OH)D3 were found in IBD patients as compared to the controls. We discovered no effect from supplementation and no association between pain severity and vitamin D.
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