4.6 Article

Acute MDPV Binge Paradigm on Mice Emotional Behavior and Glial Signature

期刊

PHARMACEUTICALS
卷 14, 期 3, 页码 -

出版社

MDPI
DOI: 10.3390/ph14030271

关键词

3,4-methylenedioxypyrovalerone; methamphetamine; behavior; glia

资金

  1. Foundation for Science and Technology (FCT, Portugal) [POCI-01-0145-FEDER-030786, UID/NEU/04539/2013, UID/NEU/04539/2019]
  2. COMPETE-FEDER [POCI-01-0145-FEDER-007440]
  3. Centro 2020 Regional Operational Programmes [CENTRO-01-0145-FEDER-000012: HealthyAging2020, CENTRO-01-0145-FEDER-000008: BrainHealth 2020]

向作者/读者索取更多资源

This study found that binge exposure to MDPV did not result in evident changes in behavior, neurochemistry, and glial cells compared to METH. Further profiling of MDPV's neuropharmacological profile at different time-points, regimens, and brain regions is needed.
3,4-Methylenedioxypyrovalerone (MDPV), a widely available synthetic cathinone, is a popular substitute for classical controlled drugs of abuse, such as methamphetamine (METH). Although MDPV poses public health risks, its neuropharmacological profile remains poorly explored. This study aimed to provide evidence on that direction. Accordingly, C57BL/6J mice were exposed to a binge MDPV or METH regimen (four intraperitoneal injections every 2 h, 10 mg/kg). Locomotor, exploratory, and emotional behavior, in addition to striatal neurotoxicity and glial signature, were assessed within 18-24 h, a known time-window encompassing classical amphetamine dopaminergic neurotoxicity. MDPV resulted in unchanged locomotor activity (open field test) and emotional behavior (elevated plus maze, splash test, tail suspension test). Additionally, striatal TH (METH neurotoxicity hallmark), Iba-1 (microglia), GFAP (astrocyte), RAGE, and TLR2/4/7 (immune modulators) protein densities remained unchanged after MDPV-exposure. Expectedly, and in sheer contrast with MDPV, METH resulted in decrease general locomotor activity paralleled by a significant striatal TH depletion, astrogliosis, and microglia arborization alterations (Sholl analysis). This comparative study newly highlights that binge MDPV-exposure comes without evident behavioral, neurochemical, and glial changes at a time-point where METH-induced striatal neurotoxicity is clearly evident. Nevertheless, neuropharmacological MDPV signature needs further profiling at different time-points, regimens, and brain regions.

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