期刊
JOURNAL OF PERSONALIZED MEDICINE
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jpm11040256
关键词
background parenchymal enhancement; breast MRI; breast cancer; neoadjuvant chemotherapy; fibro glandular tissue
资金
- Italian Ministry of Health Ricerca Finalizzata 2018
This study found that the BPE parameter could serve as a predictive marker for therapy response during neoadjuvant therapy in breast cancer patients. The variability of BPE during therapy was associated with treatment effectiveness, which could help improve decision-making in personalized medicine. Further investigations in conjunction with radiomics are warranted to validate these preliminary results.
Background: For assessing the predictability of oncology neoadjuvant therapy results, the background parenchymal enhancement (BPE) parameter in breast magnetic resonance imaging (MRI) has acquired increased interest. This work aims to qualitatively evaluate the BPE parameter as a potential predictive marker for neoadjuvant therapy. Method: Three radiologists examined, in triple-blind modality, the MRIs of 80 patients performed before the start of chemotherapy, after three months from the start of treatment, and after surgery. They identified the portion of fibroglandular tissue (FGT) and BPE of the contralateral breast to the tumor in the basal control pre-treatment (baseline). Results: We observed a reduction of BPE classes in serial MRI checks performed during neoadjuvant therapy, as compared to baseline pre-treatment conditions, in 61.3% of patients in the intermediate step, and in 86.7% of patients in the final step. BPE reduction was significantly associated with sequential anthracyclines/taxane administration in the first cycle of neoadjuvant therapy compared to anti-HER2 containing therapies. The therapy response was also significantly related to tumor size. There were no associations with menopausal status, fibroglandular tissue (FGT) amount, age, BPE baseline, BPE in intermediate, and in the final MRI step. Conclusions: The measured variability of this parameter during therapy could predict therapy effectiveness in early stages, improving decision-making in the perspective of personalized medicine. Our preliminary results suggest that BPE may represent a predictive factor in response to neoadjuvant therapy in breast cancer, warranting future investigations in conjunction with radiomics.
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