期刊
ISCIENCE
卷 24, 期 4, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2021.102310
关键词
-
资金
- European Union's Seventh Framework Program for research, technological development, and demonstration [606895]
This study conducted a cross-sectional ethnopharmacological field study in Bolivia, discovering potential antichagasic botanical drugs and identifying hydroxyanthraquinone as a potential lead scaffold for anti-Trypanosoma cruzi drugs. The research suggests that phylogenetic hotspots in the plant kingdom may be a valuable resource for drug discovery based on ethnopharmacological hypotheses.
Globally, more than six million people are infected with Trypanosoma cruzi, the causative protozoan parasite of the vector-borne Chagas disease (CD). We conducted a cross-sectional ethnopharmacological field study in Bolivia among different ethnic groups where CD is hyperendemic. A total of 775 extracts of botanical drugs used in Bolivia in the context of CD and botanical drugs from unrelated indications from the Mediterranean De Materia Medica compiled by Dioscorides two thousand years ago were profiled in a multidimensional assay uncovering different antichagasic natural product classes. Intriguingly, the phylobioactive anthraquinone hotspot matched the antichagasic activity of Senna chloroclada, the taxon with the strongest ethnomedical consensus for treating CD among the Izoceno-Guarani. Testing common 9,10-anthracenedione derivatives in T. cruzi cellular infection assays demarcates hydroxyanthraquinone as a potential antichagasic lead scaffold. Our study systematically uncovers in vitro antichagasic phylogenetic hotspots in the plant kingdom as a potential resource for drug discovery based on ethnopharmacological hypotheses.
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