期刊
ISCIENCE
卷 24, 期 6, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.isci.2021.102519
关键词
-
资金
- INSERM
- Aviesan Sino-French
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [SFB900/3 B2, 158989968]
- Joint French-German Project cGASVAC [406922110]
- LABEX ECOFECT of Lyon University, within the programInvestissements d'Avenir [ANR-11-IDEX-0007]
The cGAS/STING pathway plays a critical role in controlling paramyxovirus infection, with cGAS or STING deletion leading to reduced type I interferon production and enhanced viral infection. Phosphorylation and ubiquitination of STING during viral infections confirm the activation of the cGAS/STING pathway by NiV and MeV.
During inflammatory diseases, cancer, and infection, the cGAS/STING pathway is known to recognize foreign or self-DNA in the cytosol and activate an innate immune response. Here, we report that negative-strand RNA paramyxoviruses, Nipah virus (NiV), and measles virus (MeV), can also trigger the cGAS/STING axis. Although mice deficient for MyD88, TRIF, and MAVS still moderately control NiV infection when compared with wild-type mice, additional STING deficiency resulted in 100% lethality, suggesting synergistic roles of these pathways in host protection. Moreover, deletion of cGAS or STING resulted in decreased type I interferon production with enhanced paramyxoviral infection in both human and murine cells. Finally, the phosphorylation and ubiquitination of STING, observed during viral infections, confirmed the activation of cGAS/STING pathway by NiV and MeV. Our data suggest that cGAS/STING activation is critical in controlling paramyxovirus infection and possibly represents attractive targets to develop countermeasures against severe disease induced by these pathogens.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据