期刊
BIOMEDICINES
卷 9, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/biomedicines9040377
关键词
iron-oxide nanoparticles; SPIONs; erythrocytes; plasma; deformability; nitric oxide; osmotic resistance; hypertension; biomagnetometry
资金
- Slovak Research and Development Agency [APVV-16-0263]
- Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic
- VEGA [2/0160/17, 2/0157/21, 1/0193/21]
USPIONs administration improved erythrocyte deformability and nitric oxide production in normotensive rats but not in hypertensive rats. Hypertensive rats showed significantly lower levels of USPION-originated iron in erythrocytes and faster elimination of USPIONs compared to normotensive rats.
We determined erythrocyte physiological and biochemical properties after the single and repeated administration of ultra-small superparamagnetic iron-oxide nanoparticles (USPIONs) in normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Polyethylene glycol-coated USPIONs (transmission electron microscope detected a mean size of similar to 30 nm and hydrodynamic size similar to 51 nm) were intravenously administered to rats either in one infusion at nominal dose 1 mg Fe/kg or in two infusions (administered with a difference of 24 h) at nominal dose 2 mg Fe/kg. Results showed that USPIONs did not deteriorate erythrocyte deformability, nitric oxide production, and osmotic resistance in both experimental settings. Both the single and repeated USPION administration elevated erythrocyte deformability in WKY. However, this effect was not present in SHR; deformability in USPION-treated SHR was significantly lower than in USPION-treated WKY. Nitric oxide production by erythrocytes was increased after a single USPION treatment in WKY, so it can be associated with improvement in erythrocyte deformability. Using biomagnetometry, we revealed significantly lower amounts of USPION-originated iron in erythrocytes in SHR compared with WKY. We found a much faster elimination of USPIONs from erythrocytes in hypertensive rats compared with the normotensive ones, which might be relevant for clinical practice in hypertensive patients undergoing clinical examination with the use of iron-oxide nanoparticles.
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