The Role of Metabolism in Tumor Immune Evasion: Novel Approaches to Improve Immunotherapy

The tumor microenvironment exhibits altered metabolic properties as a consequence of the needs of tumor cells, the natural selection of the most adapted clones, and the selfish relationship with other cell types. Beyond its role in supporting uncontrolled tumor growth, through energy and building materials obtention, metabolism is a key element controlling tumor immune evasion. Immunotherapy has revolutionized the treatment of cancer, being the first line of treatment for multiple types of malignancies. However, many patients either do not benefit from immunotherapy or eventually relapse. In this review we overview the immunoediting process with a focus on the metabolism-related elements that are responsible for increased immune evasion, either through reduced immunogenicity or increased resistance of tumor cells to the apoptotic action of immune cells. Finally, we describe the main molecules to modulate these immune evasion processes through the control of the metabolic microenvironment as well as their clinical developmental status.

Automated summary

The tumor microenvironment undergoes altered metabolic properties due to the needs of tumor cells, natural selection of adapted clones, and selfish relationships with other cell types. Metabolism not only supports uncontrolled tumor growth but also plays a key role in controlling tumor immune evasion. Despite revolutionizing cancer treatment, immunotherapy may not benefit all patients, leading to eventual relapse.