Persistent Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia at 6-Months Follow-Up Assessed by Optical Coherence Tomography Angiography

Article Ophthalmology

Retinal microvascular abnormalities in patients after COVID-19 depending on disease severity

Miguel Angel Zapata et al.

Summary: This study found that patients with moderate and severe SARS-CoV-2 pneumonia had decreased central retinal vascular density.

BRITISH JOURNAL OF OPHTHALMOLOGY (2022)

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Article Ophthalmology

Optic nerve and macular optical coherence tomography in recovered COVID-19 patients

Barbara Burgos-Blasco et al.

Summary: The study suggests that recovered COVID-19 patients may experience changes in retinal layers, with an increase in global RNFLT, a decrease in macular RNFL, and an increase in ganglion cell layer thickness. Patients with anosmia and ageusia showed more pronounced alterations in these retinal layers.

EUROPEAN JOURNAL OF OPHTHALMOLOGY (2022)

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Article Medicine, General & Internal

COVID-19 retinal microangiopathy as an in vivo biomarker of systemic vascular disease?

M. F. Landecho et al.

Summary: COVID-19 is caused by SARS-CoV-2, which utilizes the ACE2 receptor to gain entry into cells. This study evaluated retinal abnormalities in asymptomatic COVID-19 patients, finding that cotton wool exudates were present in 22% of cases, indicating potential vascular disease severity. Prospective trials are needed to determine the role of antiaggregation therapy in these patients.

JOURNAL OF INTERNAL MEDICINE (2021)

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Article Infectious Diseases

Clinical sequelae of COVID-19 survivors in Wuhan, China: a single-centre longitudinal study

Qiutang Xiong et al.

Summary: The study described the common clinical sequelae in COVID-19 survivors discharged from the hospital for more than 3 months, including general symptoms, respiratory symptoms, cardiovascular-related symptoms, psychosocial symptoms, and alopecia. Female patients were more likely to experience physical decline/fatigue, postactivity polypnoea, and alopecia.

CLINICAL MICROBIOLOGY AND INFECTION (2021)

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Article Medicine, General & Internal

6-month consequences of COVID-19 in patients discharged from hospital: a cohort study (Publication with Expression of Concern. See vol. 401, pg. 90, 2023)

Chaolin Huang et al.

Summary: This study aimed to investigate the long-term health consequences of discharged COVID-19 patients and associated risk factors, particularly disease severity. Patients with more severe illness during hospitalization showed more severe impaired pulmonary diffusion capacities and abnormal chest imaging manifestations, highlighting the need for targeted interventions for long-term recovery.

LANCET (2021)

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Letter Medicine, General & Internal

Microvascular Injury in the Brains of Patients with Covid-19

Daniel P. Perl et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Ophthalmology

Optical coherence tomography angiography analysis of the retina in patients recovered from COVID-19: a case-control study

Mojtaba Abrishami et al.

Summary: The study aimed to quantify the density of macular microvasculature and the area of the foveal avascular zone (FAZ) in COVID-19 recovered patients using OCTA analysis. Results showed significantly lower vessel density in both superficial and deep retinal capillary plexus of the COVID cohort, suggesting potential retinal vascular complications in patients with coronavirus infection.

CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE (2021)

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Letter Ophthalmology

Longitudinal analysis of cotton wool spots in COVID-19 with high-resolution spectral domain optical coherence tomography and optical coherence tomography angiography

Ashish Markan et al.

CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY (2021)

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Article Biochemistry & Molecular Biology

Retinal Microvascular Impairment in COVID-19 Bilateral Pneumonia Assessed by Optical Coherence Tomography Angiography

Jorge Gonzalez-Zamora et al.

Summary: This study evaluated retinal and microvascular alterations in COVID-19 patients with bilateral pneumonia caused by SARS-COV-2, finding significant differences in retinal structure compared to controls. The findings suggest that thrombotic and inflammatory phenomena may be occurring in the retina of COVID-19 patients. Further research is needed to analyze the longitudinal evolution of these changes and their correlation with disease severity.

BIOMEDICINES (2021)

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Review Cardiac & Cardiovascular Systems

Microvascular Angiopathic Consequences of COVID-19

Margaret Nalugo et al.

Summary: The COVID-19 pandemic has rapidly spread worldwide, causing multi-organ complications primarily due to endothelial cell dysfunction and microvascular thrombosis.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

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Article Medicine, Research & Experimental

Long-term microstructure and cerebral blood flow changes in patients recovered from COVID-19 without neurological manifestations

Yuanyuan Qin et al.

Summary: The study found that COVID-19 patients showed severe changes in gray matter, white matter, and cerebral blood flow, especially in patients with severe disease. These changes were significantly correlated with inflammatory markers, suggesting that the inflammatory storm may cause indirect brain damage.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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News Item Medicine, General & Internal

Covid-19: Middle aged women face greater risk of debilitating long term symptoms

Ingrid Torjesen

BMJ-BRITISH MEDICAL JOURNAL (2021)

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Article Medicine, General & Internal

Reduced retinal vessel density in COVID-19 patients and elevated D-dimer levels during the acute phase of the infection

Noemi Guemes-Villahoz et al.

Summary: The study examined macular vessel density and perfusion in COVID-19 patients using OCTA technology, finding significant changes, particularly in patients with elevated D-Dimer levels. These retinal vascular abnormalities may be associated with the prothrombotic state induced by SARS-CoV-2 infection.

MEDICINA CLINICA (2021)

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Letter Medicine, General & Internal