期刊
COMPOSITES COMMUNICATIONS
卷 26, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.coco.2021.100785
关键词
Nanofibrous hydrogels; Sequential crosslinking; Bio-adhesiveness; Wound healing
资金
- National Natural Science Foundation of China [81771338, 52073055]
- Natural Science Foundation of Shanghai [19ZR1470500]
Inspired by the protein secretion-curing process of natural marine mussels, an adhesive nanofibrous hydrogel was developed using a sequential crosslinking strategy. The hydrogel showed superior adhesive and tensile properties, accelerating wound healing and demonstrating great potential for joint wound care.
Despite recent progress in hydrogel wound dressings, joint wound treatment remains an ongoing challenge due to their poor adhesive and stretchable properties. Herein, inspired by protein secretion-curing process of natural marine mussels, an adhesive nanofibrous hydrogel is developed via a sequential crosslinking strategy. Firstly, to avoid uncontrolled self-polymerization of dopamine (DA), DA grafted gelatin (GT) nanofibers are fabricated via electrospinning under pH value around 4. Further, the fibrous hydrogels are in-situ crosslinked under pH value of about 8 to strengthen the intermolecular interaction within fibers. The DA crosslinked GT fibrous hydrogels via Michael addition and Schiff base reaction exhibit superior adhesive and tensile properties which are 1.5 times and 3.1 times higher than those of GT fibrous hydrogels, respectively. The in vitro cytocompatibility tests and in vivo wound healing study further prove that GT grafted DA nanofibrous hydrogels are able to accelerate wound healing. Taken together, we demonstrate a simple and versatile strategy for generating adhesive and stretchable nanofibrous hydrogel, showing a great potential for joint wound care.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据