Effect of Stroke on Contralateral Functional Connectivity

Introduction: Stroke can induce large-scale functional reorganization of the brain; however, the spatial patterns of this reorganization remain largely unknown. Methods: Using a large (N = 116) sample of participants who were in the chronic stages of stroke, we present a systematic study of the association between brain damage and functional connectivity (FC) within the intact hemisphere. We computed correlations between regional cortical damage and contralateral FC. Results: We identified left-hemisphere regions that had the most pronounced effect on the right-hemisphere FC, and, conversely, right-hemisphere connections where the effect of damage was particularly strong. Notably, the vast majority of significant correlations were positive: damage was associated with an increase in regional contralateral connectivity. Discussion: These findings lend evidence of the reorganization of contralateral cortical networks as a response to brain damage, which is more pronounced in a set of well-connected regions where connectivity increases with the amount of damage.

Automated summary

Using a large sample of 116 participants who had experienced stroke, this study systematically examined the relationship between brain damage and functional connectivity within the intact hemisphere. The findings suggest evidence of contralateral cortical network reorganization in response to brain damage, particularly in well-connected regions where connectivity increases with the degree of damage.