期刊
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
卷 7, 期 2, 页码 171-179出版社
ELSEVIER
DOI: 10.1016/j.bpsc.2021.04.011
关键词
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资金
- National Science Foundation [DGE-1752134]
- National Institutes of Health [U01 MH081902, P50 MH066286, U01 MH081857, U01 MH82022, U01 MH081984, U01 MH081944, U01 MH082004, R01 MH076989, U01 MH081928, U01 MH081988]
This study investigates the relationship between life event stress (LES) and cortical thickness in individuals at clinical high risk for psychosis (CHR-P). The findings suggest that LES is associated with reduced baseline cortical thickness in both CHR-P and healthy individuals. It is also found that CHR-P status is linked with thinner cortex in select regions even after controlling for LES.
BACKGROUND: A decline in cortical thickness during early life appears to be a normal neuromaturational process. Accelerated cortical thinning has been linked with conversion to psychosis among individuals at clinical high risk for psychosis (CHR-P). Previous research indicates that exposure to life event stress (LES) is associated with exaggerated cortical thinning in both healthy and clinical populations, and LES is also linked with conversion to psychosis in CHR-P. To date, there are no reports on the relationship of LES with cortical thickness in CHR-P. This study examines this relationship and whether LES is linked with cortical thinning to a greater degree in individuals at CHR-P who convert to psychosis compared with individuals at CHR-P who do not convert and healthy control subjects. METHODS: Controlling for age and gender (364 male, 262 female), this study examined associations between LES and baseline cortical thickness in 436 individuals at CHR-P (375 nonconverters and 61 converters) and 190 comparison subjects in the North American Prodrome Longitudinal Study. RESULTS: Findings indicate that prebaseline cumulative LES is associated with reduced baseline cortical thickness in several regions among the CHR-P and control groups. Evidence suggests that LES is a risk factor for thinner cortex to the same extent across diagnostic groups, while CHR-P status is linked with thinner cortex in select regions after accounting for LES. CONCLUSIONS: This research provides additional evidence to support the role of LES in cortical thinning in both healthy youth and those at CHR-P. Potential underlying mechanisms of the findings and implications for future research are discussed.
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