期刊
BIOENGINEERING & TRANSLATIONAL MEDICINE
卷 6, 期 2, 页码 -出版社
WILEY
DOI: 10.1002/btm2.10218
关键词
catheter‐ related bladder discomfort; indwelling urinary catheters; lidocaine; local drug delivery; sustained drug delivery
资金
- National Research Foundation of Korea [2019019401, 2021R1A2B5B03001914]
- National Research Foundation of Korea [2021R1A2B5B03001914] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study proposed a urinary catheter with a drug-loaded polymer strand to relieve bladder discomfort caused by catheter insertion. The drug-delivery IUC showed sustained pain relief effects for up to 7 days and reduced the expression of pain-related inflammatory markers in biopsied bladder tissues.
Indwelling urinary catheters (IUCs) are used in clinical settings to assist detrusor contraction in hospitalized patients. However, an inserted IUC often causes catheter-related bladder discomfort. To resolve this, we propose an IUC coupled with local, sustained release of an anesthetic drug, lidocaine. For this, a thin strand composed of poly (lactic-co-glycolic acid) and lidocaine was separately prepared as a drug delivery carrier, which was then wound around the surface of the IUC to produce the drug-delivery IUC. Our results revealed that the drug-delivery IUC could exert the pain-relief effects for up to 7 days when placed in the bladder of living rats. Cystometrogram tests indicated that the drug-delivery IUC could significantly relieve bladder discomfort compared with the IUC without lidocaine. Furthermore, the expression of pain-related inflammatory markers, such as nerve growth factor, cyclooxygenase-2, and interleukin-6 in the biopsied bladder tissues was significantly lower when the drug-delivery IUC was used. Therefore, we conclude that an IUC simply assembled with a drug-loaded polymer strand can continuously release lidocaine to allow for the relief of bladder discomfort during the period of IUC insertion.
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