期刊
NPJ REGENERATIVE MEDICINE
卷 6, 期 1, 页码 -出版社
NATURE PORTFOLIO
DOI: 10.1038/s41536-021-00133-3
关键词
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资金
- European Union [676338]
- European Research Council (ERC) under the European Union's Horizon 2020 research and innovation programme [866126]
- Science Foundation Ireland, Career Development Award [15/CDA/3629]
- Science Foundation Ireland, Frontiers for the Future [19/FFP/6982]
- Science Foundation Ireland/European Regional Development Fund [13/RC/2073]
Cell-based scaffold-free therapies aim to create in vitro organotypic three-dimensional tissue-like surrogates, but they still face challenges in terms of cost and technology transfer in clinical applications. While automation systems have been implemented, achieving efficient scaffold-free organogenesis remains difficult.
Cell-based scaffold-free therapies seek to develop in vitro organotypic three-dimensional (3D) tissue-like surrogates, capitalising upon the inherent capacity of cells to create tissues with efficiency and sophistication that is still unparalleled by human-made devices. Although automation systems have been realised and (some) success stories have been witnessed over the years in clinical and commercial arenas, in vitro organogenesis is far from becoming a standard way of care. This limited technology transfer is largely attributed to scalability-associated costs, considering that the development of a borderline 3D implantable device requires very high number of functional cells and prolonged ex vivo culture periods. Herein, we critically discuss advancements and shortfalls of scaffold-free cell-based tissue engineering strategies, along with pioneering concepts that have the potential to transform regenerative and reparative medicine.
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