期刊
BIOACTIVE MATERIALS
卷 6, 期 5, 页码 1452-1463出版社
KEAI PUBLISHING LTD
DOI: 10.1016/j.bioactmat.2020.10.026
关键词
Mesoporous silica film; Vertical aligned mesochannels; Titania nanotubes array; Drug delivery; Osteoblasts
资金
- National Natural Science Foundation of China [81530051, 31800790, 31670966]
- Shaanxi Provincial Key Research and Development Plan Project [2019SF-031]
- Young Talent fund of University Association for Science and Technology in Shaanxi, China [20190304]
- Danmarks Frie Forskningsfond [9040-00219B]
- Carlsbergfondet
A new method has been used to prepare vertically aligned mesoporous silica thin film with better performance for bone implant surface coating.
Mesoporous silica thin film has been widely used in various fields, particularly the medical implant coating for drug delivery. However, some drawbacks remain with the films produced by traditional method (evaporation-induced self-assembly, EISA), such as the poor permeability caused by their horizontal aligned mesochannels. In this study, the vertical aligned mesoporous silica thin film (VMSTF) is uniformly grown alongside the walls of titania nanotubes array via a biphase stratification growth method, resulting in a hierarchical two-layered nanotubular structure. Due to the exposure of opened mesopores, VMSTF exhibits more appealing performances, including rapid degradation, efficient small-molecular drug (dexamethasone) loading and release, enhanced early adhesion and osteogenic differentiation of MC3T3-E1 cells. This is the first time successfully depositing VMSTF on nanoporous substrate and our findings suggest that the VMSTF may be a promising candidate for bone implant surface coating to obtain bioactive performances.
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