期刊
ASIAN JOURNAL OF PSYCHIATRY
卷 58, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.ajp.2021.102621
关键词
Schizotypy; Cortico-striatal connectivity; Resting-state fMRI
类别
资金
- Chinese University of Hong Kong
- Research Grants Council [14605717, 14612519]
- National Key Research and Development Programme [2016YFC0906402]
- CAS Key Laboratory of Mental Health, Institute of Psychology
The research found impaired cortico-striatal connectivity in individuals with a high level of schizotypy, but improvements over time. The connectivity between the dorsal striatum and the insula may serve as a marker for temporal changes in positive schizotypy.
Purpose of the research: Cortico-striatal functional connectivity has been implicated in the neuropathology of schizophrenia. However, the longitudinal relationship between the cortico-striatal connectivity and schizotypy remains unknown. We examined the resting-state fMRI connectivity in 27 individuals with a high level of schizotypy and 20 individuals with a low level of schizotypy at baseline and 18 months later. Correlations between changes in cortico-striatal connectivity and changes in schizotypy scores over time were examined. Principal results: We found both increased and decreased cortico-striatal connectivity in individuals with a high level of schizotypy at baseline. Over time, these individuals showed improvement in both the negative and positive schizotypal domains. Changes in striatal-insula connectivity were positively correlated with changes in positive schizotypy from baseline to follow-up. Major conclusions: Our results suggested impaired cortico-striatal connectivity in individuals with a high level of schizotypy. The dysconnectivity mainly involves the dorsal striatum. The connectivity between the dorsal striatum and the insula may be a putative marker for temporal changes in positive schizotypy.
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