期刊
FRONTIERS IN VETERINARY SCIENCE
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fvets.2021.626579
关键词
Taenia hydatigena; scolex; cyst; cestode; proteome
资金
- National Natural Science Foundation of China [U1703104, 31472185]
The study used LC-MS/MS to profile the proteomes of Taenia hydatigena cyst scolex and the cyst without scolex, identifying 764 different proteins. Comparative analysis showed that proteins associated with growth and development were more abundant in CS, while proteins constituting a scaffolding and protective extracellular matrix were more abundant in CWS. Validation by Western blotting confirmed higher abundance of selected proteins in CWS compared to CS.
Taenia hydatigena, a globally distributed parasite, is a canine tapeworm and causes huge economic losses in the food industry. Using LC-MS/MS, the proteomes of T. hydatigena cyst scolex, designated as CS, and the cyst without the scolex, designated as CWS, were profiled and a total of 764 different proteins were identified, 664 of which were identified in CS, 412 identified in CWS, and 312 in both. Comparative analysis revealed that CS had more abundant proteins associated with growth and development, while CWS had more abundant proteins constituting a scaffolding and protective extracellular matrix. Consistent with the sequencing data, the abundance of the five selected proteins was validated to be higher in CWS than CS by Western blotting. The current data will provide a clue for further pinpointing a role of these proteins in the biology of T. hydatigena.
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