期刊
DIAGNOSTICS
卷 11, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/diagnostics11030511
关键词
coronary artery disease; acute myocardial infarction; psoas muscle; inflammation; atherosclerosis; positron-emission tomography
资金
- Korea University Anam Hospital [K2014011, O2000601]
This study found that metabolic activity of psoas muscle is associated with carotid artery inflammation and acute myocardial infarction (AMI), suggesting that psoas muscle activity is related to coronary plaque vulnerability and may be useful for predicting the risk of AMI.
Inflamed skeletal muscle promotes chronic inflammation in atherosclerotic plaques, thereby contributing to the increased risk of coronary artery disease (CAD). In this study, we evaluated the metabolic activity of psoas muscle, using F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT), and its association with carotid artery inflammation and acute myocardial infarction (AMI). In total, 90 participants (32 AMI, 33 chronic stable angina (CSA), and 25 control) were enrolled in this prospective study. Metabolic activity of skeletal muscle (SM) was measured by using maximum standardized uptake value (SUVmax) of psoas muscle, and corresponding psoas muscle area (SM area) was also measured. Carotid artery inflammation was evaluated by using the target-to background ratio (TBR) of carotid artery. SM SUVmax was highest in AMI, intermediate in CSA, and lowest in control group. SM SUVmax was significantly correlated with carotid artery TBR and systemic inflammatory surrogate markers. Furthermore, SM SUVmax was independently associated with carotid artery TBR and showed better predictability than SM area for the prediction of AMI. Metabolic activity of psoas muscle assessed by F-18-FDG PET/CT was associated with coronary plaque vulnerability and synchronized with the carotid artery inflammation in the participants with CAD. Furthermore, it may also be useful to predict AMI.
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